Early research provides clues to the causes of spontaneous coronary artery dissection (SCAD) and suggests special considerations for patient care. This collection of articles traces the development of SCAD research, and will be updated with the most recent science as it becomes available.

A Look Back…


Why Heart Attacks Are Striking Healthy Young Womenby Kristen Dahlgren, Lauren Dunn, and Parminder Deo, NBC News Health, DEC 20 2016, 7:33 PM ET

SCAD: Women Beware. Cardiologists missing uncommon heart condition, ABC-KSAT12, Contributors include: Wendy Chioji, Field Producer; Roque Correa, Editor; Rusty Reed, Videographer.

ECG of the Month: Young, Post-partum Woman Presenting with Chest Pain and ST Elevation, Gregg G. Gerasimon, MD, FACC, Dec 02, 2016

What causes healthy young women to suffer heart attacks?, Massachusetts General Hospital studies dangers of extreme physical activity, emotional stress, Emily Riemer, ABC-WCVB5, 6:44 PM EST Nov 8, 2016

Spontaneous Coronary Artery Dissection, Marysia S. Tweet, Rajiv Gulati, Sharonne N. Hayes, Tweet, M.S., Gulati, R. & Hayes, S.N. Curr Cardiol Rep (2016) 18: 60. doi:10.1007/s11886-016-0737-6

Contemporary Review on Spontaneous Coronary Artery DissectionJacqueline Saw, G.B. John Mancini, Karin H. Humphries, 

New Mom Heart Attack Risk (at minute 2:22), CBC News: Ottawa July 22, 2016

High-Risk Cardiac Disease in Pregnancy,Uri Elkayam, Sorel Goland, Petronella eper, Candice K. Silversides, 

Outcomes of patients with spontaneous coronary artery dissection, 2 August 2016: McGrath-Cadell L, McKenzie P, Emmanuel S, et al. Open Heart 2016;3:e000491. doi:10.1136/openhrt-2016- 000491

SCAD – Spontaneous Coronary Artery Dissection Cleveland Clinic webchat, (Esther Kim, MD 07/01/16)

SCAD – Spontaneous Coronary Artery Dissection Cleveland Clinic webchat, (Dr. Esther Kim 07/24/15)

Spontaneous coronary artery dissection—A review, Amelia Yip and Jacqueline Saw, Cardiovasc Diagn Ther. 2015 Feb; 5(1): 37–48. doi:  10.3978/j.issn.2223-3652.2015.01.08


“What Clinicians Should Know About Spontaneous Coronary Artery Dissection” Tweet, Gulati and Hayes, Mayo Clin Proc, August 2015;90(8):1125-1130.

“Education is Key in Spreading Awareness …” Malissa Wood and Sahar Naderi, (video), June 15, 2015.

“Stent mal-apposition with resorption of intramural hematoma with spontaneous coronary artery dissection,”  Lempereur, Fung, Saw, Cardiovascular Diagnosis and Therapy, 2015.

“Spontaneous Coronary Artery Dissection in the Emergency Department,” Shafer and Gonzales, May 14, 2015,

“Prevalence of Extracoronary Vascular Abnormalities and Fibromuscular Dysplasia in Patients with Spontaneous Coronary Artery Dissection,” Prasad, Tweet, Hayes et al. The American Journal of Cardiology, Volume 115, Issue 12, 1672-1677.

“Management and Long-Term Prognosis of Spontaneous Coronary ArteryDissection,” Lettieri, et al. The American Journal of Cardiology, Volume 116, Issue 1, 66-73

“Familial Spontaneous Coronary Artery Dissection: Evidence for Genetic Susceptibility,” (Mayo Clinic announcement with video) Goel, Tweet, Hayes et al. JAMA Intern Med. 2015; 175(5):821-826. 

“Spontaneous coronary artery dissection: novel insights on diagnosis and management,” Fernando Alfonso, et al. Cardiovascular Diagnosis and Therapy, 2015;5(2):133-140.

“Spontaneous Coronary Artery Dissection: A Review,” Yip and Saw, Cardiovascular Diagnosis and Therapy 2015;5(1):37-48. 

“Learn the Signs of Spontaneous Coronary Artery Dissection” E. Kim, Heart Advisor, January 2015.

“Spontaneous Coronary Artery Dissection (SCAD) Patient Page,” Saw, et al. Circulation. 2015;131:e3-e5. 


“Spontaneous Coronary Artery Dissection — Revascularization Versus Conservative Therapy,” Tweet, Hayes, et al. Circulation: Cardiovascular Interventions. 2014; 7: 777-786

“Spontaneous Coronary Artery Dissection — From Diagnosis to Management,” Circulation Journal of the Japanese Circulation Society, (Circ J 2014; 78: 2099–21)

“Coronary Artery Tortuosity in Spontaneous Coronary Artery Dissection: Angiographic Characteristics and Clinical Implications,” Elied, Guddeti, Tweet et al. Circulation: Cardiovascular Interventions.

“Spontaneous Coronary Artery Dissection (SCAD): New Insights into This Not-So-Rare Condition,” Sharonne N. Hayes (2014), Texas Heart Institute Journal, Vol. 41, No. 3, pp. 295-298.

“Spontaneous Coronary Artery Dissection–Don’t Miss It,” Robert D. Simari, MD; Rajiv Gulati, MD, PhD, MedScape (video) March 4, 2014.


Clinical features of spontaneous coronary artery dissection, Japanese College of Cardiology, Journal of Cardiology.

Prevalence of spontaneous coronary artery dissection in patients with acute coronary syndrome, European Heart Journal: Acute Cardiovascular Care


“Long-Term Follow-Up of a Large Series of Patients Prospectively Managed With a “Conservative” Therapeutic Strategy,” JACC Cardiovascular Interventions.

“Clinical Features, Management and Prognosis of Spontaneous Coronary Artery Dissection,” Journal of the American Heart Association, Circulation.


“Management of Spontaneous Coronary Artery Dissection in the Primary Percutaneous Coronary Intervention Era,” David Adlam, Journal of Invasive Cardiology.


“Spontaneous dissections of coronary arteries and acute coronary syndromes: rationale and design of the DISCOVERY, a multicenter prospective registry with a case-control group,” Journal of Cardiovascular Medicine.

“Spontaneous coronary artery dissection: a Western Denmark Heart Registry study,” Catheter Cardiovascular Interventions, retrospective study 1999-2007.


“Acute Myocardial Infarction Associated with Pregnancy,” Uri Elkayam, Annals of Internal Medicine, Vol. 125, No. 9.


Clinical Course and Long-Term Prognosis of Spontaneous Coronary Artery Dissection, Mark Silverman, The American Journal of Cardiology,


Original description of SCAD in The British Medical Journal by Harold C. Pretty: “DISSECTING ANEURYSM OF CORONARY ARTERY IN A WOMAN AGED 42: RUPTURE”

Summary Documents

Spontaneous Coronary Artery Dissection (SCAD)

This article in AHA’s journal Circulation is a summary of SCAD to share with your doctor:

Fibromuscular Dysplasia (FMD)

This Circulation article is a summary of FMD, an associated condition of SCAD, to help inform you and share with your doctor: